Ascot Vale, a residential suburb between Flemington and Moonee Ponds, is 6 km north-west of Melbourne. Its western boundary is the Maribyrnong River and its eastern boundary is the Moonee Ponds Creek. Until 1998 the suburb of Travancore was partly in Ascot Vale.
Ascot Vale's eastern sector is transected by Mount Alexander Road, the main route to the gold diggings at Bendigo and Castlemaine (1851). Its name probably survives from its proximity to the Flemington racecourse, as Ascot is a famous English racecourse.